Does Diet Coke Spike Insulin? Is Diet Coke associated with an increase in insulin levels? While diet sodas like Diet Coke contain artificial sweeteners that are often calorie-free, studies suggest that these sweeteners might still trigger insulin release. However, the evidence on the exact impact of diet sodas on insulin levels remains inconclusive. Learn more about the association between Diet Coke and insulin levels Does drinking Diet Coke lead to weight gain? While Diet Coke itself doesn’t contain calories and can be consumed as part of a balanced diet, excessive consumption of any beverage, including diet sodas, can contribute to…